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If you get sharp twinges from cold or sweet foods, a desensitizing toothpaste can help — but not all work the same way. Standard high-fluoride formulas strengthen enamel over time; Novamin (calcium sodium phosphosilicate) works faster by physically plugging exposed dentine tubules; potassium nitrate calms the nerve itself. Hydroxyapatite is a newer option that trials show performs comparably to fluoride for sensitivity and early decay protection.